Defining Human Pluripotency
نویسندگان
چکیده
منابع مشابه
Human pluripotency
Pluripotent cells have unique properties of self-renewal while maintaining developmental potential to differentiate into all three germ layers. By definition, pluripo-tent cells have no predetermined lineage program, thereby forming the fundamental basis of enquiry and experimental investigations to understand cell fate decisions. Molecular and cellular insights into human pluripotent stem cell...
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The genetic mechanisms governing human pre-implantation embryo development and the in vitro counterparts, human embryonic stem cells (hESCs), still remain incomplete. Previous global genome studies demonstrated that totipotent blastomeres from day-3 human embryos and pluripotent inner cell masses (ICMs) from blastocysts, display unique and differing transcriptomes. Nevertheless, comparative gen...
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George Q. Daley,1,2,* M. William Lensch,1,2 Rudolf Jaenisch,3 Alex Meissner,2,4 Kathrin Plath,5 and Shinya Yamanaka6,7 1Children’s Hospital Boston, Division of Hematology/Oncology, 300 Longwood Avenue, Boston, MA 02115, USA 2Harvard Stem Cell Institute, 42 Church Street, Cambridge, MA 02138, USA 3Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department o...
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Human pluripotent stem (hPS) cells provide an attractive opportunity for the manufacture of a wide array of therapeutic cell types. The challenges to commercialization include the thousand-fold diversity of cell types emerging from hPS cells and the associated difficulties in validating processes to reliably generate cells with precise identity and purity. Improved methods of controlling the do...
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The rodent naive pluripotent state is believed to represent the preimplantation inner cell mass state of the developing blastocyst and can derive self-renewing pluripotent embryonic stem cells (ESCs) in vitro. Nevertheless, human ESCs exhibit epigenetic, metabolic, and transcriptomic characteristics more akin to primed pluripotent stem cells (PSCs) derived from the postimplantation epiblast. Un...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2019
ISSN: 1934-5909
DOI: 10.1016/j.stem.2019.06.010